辛耘知識分享家:機械力拉伸動態細胞培養

ATMS動態細胞培養系統

辛耘知識分享家

機械力拉伸動態細胞培養

2024年4月電子報

半導體設備廠辛耘（3583）跨足生醫領域，2024年4月取得勝浥國際獨家總經銷。

辛耘獨家代理的多功能動態培養系統，目的利用工程的理論和細胞生物力學的技術來解決當今醫學上重要的問題。該項產品被牛津大學客戶引用於Current Biology在生化化學與分子生物學領域國際期刊排名31/285（Impact factor, IF 10.8），及北京大學客戶引用於Circulation Research 心血管研究領域國際期刊排名6/142 （Impact factor, IF 24.1）。(許多發表的Paper標於文章後)

辛耘有鑒於當前基礎生物醫學研究與創新教學，多數還停留在1885年承襲至今的二維靜態培養技術，其與體內動態的細胞生理環境差距甚大，因細胞在體內其實時時刻刻都在作動，並非靜態不動。為了進一步佐證，僅能單憑二維靜態培養的數據立即馬上犧牲實驗動物來求證，但動物實驗往往因動物個體差異、實驗冗長、龐大經費、動物培養的環境與真實人類面臨的外在環境不同，而導致結果有所差異。所以全球生醫推動替代方案，期能加速建立可以和動物實驗互補搭配的替代技術，推升生醫研究品質。

真正的生理學涉及了細胞對物理和化學信號的綜合回應，這種綜合回應是由多種因素共同作用而成的。通過這種細胞整合機制，我們可以進一步瞭解細胞受機械/化學刺激啟動的機制，而這在靜態培養條件下是無法實現的。

當細胞受到機械力刺激時，可能會導致基因表達、蛋白質分泌和細胞行為等方面的改變。機械刺激啟動的蛋白質在健康和疾病中扮演著重要角色，通過一系列的機制影響著細胞的生理功能。例如，它們可能調節細胞的形態變化、運動性能和細胞間相互作用，進而影響組織和器官的結構與功能。

ATMS動態培養系統可以模擬細胞在生理條件下所受到的複雜刺激，從而更接近真實生理狀態。ATMS動態培養系統也有助於識別細胞在不同支架類型下的生長、分化和反應等特性，為研究和改進3D生物材料結構提供重要參考。通過這些方法，我們可以更好地理解細胞與支架之間的相互作用，優化生物材料的設計，以促進細胞增殖和分化，從而更好地應用於醫學和生物工程領域。

辛耘另一篇電子報：創新細胞生物力學介紹及應用

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ATMS動態細胞培養系統

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6合1，多功能且容易操作，可以放至烘箱、低氧設備、也可以架設在顯微鏡下觀察

TAIHOYA All in One system with multiple funcions.png

辛耘可提供服務之產品介紹

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辛耘獨家代理TAIHOYA致力於生物醫學研究設備產業，推出擬人化動態培養裝置刺激細胞培養，期許不但能減少實驗動物的犧牲，更能獲得有利的實驗結果。

動態細胞仿生拉伸培養系統

TAIHOYA 動態細胞仿生拉伸培養系統.png

◎應用廣泛搭配不同細胞及拉伸與頻率參數

◎無須抹真空油，避免實驗污染

◎操作簡便，可擴充在培養箱內

◎配件可滅菌，降低操作汙染風險

◎光學、親和性無邊矽膠培養薄膜設計，可於免疫染色或螢光顯微鏡下觀察

Ø更多資訊8

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