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  Chemistry and Biotechnology - Fluence - Protein and Polymerization Rate Analyzer



Protein and Polymerization Rate Analyzer
ARGEN, by Fluence Analytics, adds another powerful tool to the arsenal of biopharmaceutical and polymer scientists. This static light scattering instrument measures the pharmaceutical stability of therapeutic proteins and peptides and the quality of natural and synthetic polymers. The instrument is composed of 16 independent cuvette sample cells capable of precise control of thermal, chemical and mechanical stress. By continuously monitoring the state of its samples, the lab instrument provides continuous, kinetic data yielding early detection of aggregation, degradation and particle formation under independently controlled stressor conditions.
Main Features:
icon 1. Swap in and out a sample from any cell without affecting the others.
2. Control the thermal, mechanical and chemical stressors for each cell.
3. Constantly monitor and reveal the kinetics of the sample evolution.
4. Test high and low sample concentrations with its large dynamic range.
5. Test sample volumes ranging from 30μL to 3.5mL.
6. Early detection of aggregation, degradation and particle formation.
7. Calculate molecular weight and virial coefficients with absolute light scattering measurements.
Standard Certification:
icon
Application:
icon Mw/Mo:
Continuously evolving size of molecule with relation to initial, pre-stressed, molecule size.
Aggregation Rate: AR=d[Mw/Mo]/dt
Time dependent Aggregation Rate in terms of Mw/Mo of which a sample undergoes any change in molecular size
Mass Aggregation Rate: Mass AR=d(Mw)/dt
Time dependent Aggregation Rate in terms of g/mole of mass added to the weight average Molecular Weight of a scatterer.
Specification:
icon ●16 fully independent sample cells, each with the following features:
> Continuous monitoring of vertically polarized scattered light at 90 degrees from incident
laser source (incident laser wavelength = 660 nm)
> Sample volume from 0.045 – 3.5 mL with selection of various sample cells
> Data sample logging rate from 1 sample / hour (0.000278 Hz) to 10 samples / second (10 Hz)
> Selectable laser power: 30 mW, 9.6 mW, 3.0 mW, 0.9 mW, 0.3 mW, 0.09 mW, 0.03 mW
> Temperature control from 18°C up to 100°C
> Stirring control from 0 to 2000 RPM, clockwise or counterclockwise
●Graphical User Interface (GUI) control of all the parameters listed above, through PC based software
●Data logging to a SQL database
●Analysis application for simplified search and recovery of data files and determination of Mw/Mo and Aggregation Rate (AR)
●Power requirements: 120VAC, 60 Hz, 1600 W
●Size: 28-5/8” W x 20” D x 13-1/8” H
●Weight: 90 lbs
 
 
 
 
 
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